TABLE 1.

Effect of oxygen deprivation on etoposide-induced G2/M arrest in SW480 colon cancer cells

Oxygen status and drug treatmentCell cycle phase distributiona
% of cells in G1 phase% of cells in S phase% of cells in G2/M phase
Normoxia
    Control52.6 ± 4.531.5 ± 0.715.9 ± 3.9
    Etoposide39.1 ± 0.828.3 ± 1.732.5 ± 2.2
Anoxia
    Control48.1 ± 4.831.9 ± 1.320.1 ± 3.5
    Etoposide40.6 ± 1.227.4 ± 1.332.1 ± 2.2
  • a Mean ± SE for the percentage of cells in each cell cycle phase as determined by flow cytometric analysis of propidium-bound DNA.