TABLE 1.

Comparison of eIF4A-binding activity and inhibition of translation between wild-type and mutant Pdcd4s

MutantBinding or inhibitiona
WTD180ND253AL354MD418AV430AD235A, D418A
eIF4A binding+++++++++++++
Inhibition of translation++++++
  • a +++, strong binding; ++, medium binding or inhibition; +, weak binding or inhibition; −, no inhibition.