TABLE 2.

Genes that are specific to the signaling domains of the ICD of the GHR

GeneChangeaKnown GH- regulated genesb
AFFY IDdNameGHR−/−Mutant 391Mutant 569
FoldTypeFoldTypeFoldType
Genes not changed in mutant 569
    95620_at2310016E22Rik2.3I2.0I1.4NC
    95471_atCdkn1c2.1I2.6I1.1NC
    93581_atNdufb82.7I2.4I1.3NC
    104072_atApcs−2.7D−2.8D−1.3NC
    99941_atEs31<−10*D<−10*D−1.4NC
    103963_f_atligp-pending−3.8D−3.0D1.1NC
    96938_atKeg1<−10*D<−10*D−1.5NC
    97680_atMug-ps1−2.3D−2.5D−1.2NC
    101910_f_atMup1−4.2D−3.8D−1.3NC+
    161815_f_atMup1−5.0D−5.9D−1.3NC+
    102096_f_atMup1−5.9D−6.5D−1.4NC+
    101566_f_atMup1−3.9D−2.6D−1.1NC+
    101909_f_atMup3−4.0D−3.7D−1.3NC
    101682_f_atMup4−4.3D−4.3D−1.3NC
    101635_f_atMup5−4.0D−3.5D−1.3NC
Genes changed in mutant 569 and not different between mutant 391 and GHR−/− mice
    95546_g_atIgf-1<−10*D<−10*D−1.5Dc+
    99475_atSocs2<−10*D<−10*D−1.2Dc+
Genes not changed in mutant 569 and mutant 391
    93986_at2410003A14Rik2.1I1.1NC1.2NC
    94844_at2810465O16Rik−2.8D−1.1NC−1.2NC
    97201_s_at2900002J19Rik2.0I1.3NC0.0NC
    102804_atCeacam1−2.3D−1.3NC−1.1NC
    160711_atDecr12.4I1.6NC1.2NC+
    92571_atHspa42.0I−1.1NC−1.1NC+
    162006_r_atImmt−4.2D−1.3NC−1.1NC
    94056_atScd1−2.4D−1.3NC0.0NC+
    93348_atTimm222.0I−1.3NC1.3NC
Genes gradually changing in mutant 569, mutant 391, and GHR−/− mice
    99669_atLgals13.2I1.9NC−1.1NC
    161161_r_atNme1−5.3D−1.9NC−1.2NC
    100437_g_atOrm1−2.7D−5.5D−1.7D+
    95030_atPrlr−4.9D−2.3D−1.7Dc+
    99591_i_atRdh11−3.3D−2.0D−1.6NC
    103465_f_atSaa23.6I1.6NC1.3NC
    93084_atSlc25a43.1I1.4NC1.1NC
    161257_r_atSnx17−4.4D−2.6Dc−1.7NC
Genes changed in mutant 391 only
    98401_atHsd3b3−1.1NC−3.1D−1.1NC
    102729_f_atHsd3b6−1.3NC−3.0D−1.2NC
  • a Values are changes with WT values as a baseline. Change types were identified by MAS 5.0 software in comparison to the WT base file: NC, no change; I, increase; D, decrease. *, transcript absent in mutant mice as determined by MAS 5.0 software.

  • b +, regulation detected.

  • c Decrease or increase in seven of nine comparisons (indicating a likely change).

  • d AFFY ID, Affymetrix identification number.