TABLE 1.

Genes regulated concordantly in mutant 569, mutant 391, and GHR−/− mice

GeneFold changeaKnown regulation by GHb
Mutant 569/WTMutant 391/WTGHR−/−/ WT
Genes upregulated in all three groups
    Ang2.13.32.8
    Cyp2b95.210.915.3
    Cyp4a102.12.62.0
    Cyp17a13.44.02.5
    Gsta42.22.54.7
    Gstt11.62.21.6
    Hao33.811.79.4+
    Papps21.63.02.3
    Serpina62.02.63.1+
    Sth2>10*>10*>10*+
    Sultn1.82.41.9
Genes downregulated in all three groups
    1100001G20−3.0<−10†<−10†
    Comt−1.9−4.2−2.8+
    Csad−2.6−6.2−6.1
    Egfr 101841_at−2.5<−10†<−10†+
    Egfr 101842_g_at<−10†<−10†<−10†+
    Fabp5−3.3−4.1−4.6
    Hsd3b5−24.7<−10†<−10†
    Igfals−1.8<−10†<−10†+
    Orm1−1.8−5.5−2.7+
  • a Values indicate changes with WT values as a baseline. *, transcript absent in WT mice; †, transcript absent in mutant mice as determined by MAS 5.0 software.

  • b +, regulation detected.