TABLE 1.

Putative Set2 homologs identified by PSI-BLAST searching with the SRI domain

SpeciesGene nameaGI accessionSequence position of putative SRI domain% Identity/similarity to SRI domainb
S. cerevisiaeSet26322293619-718NA
Candida albicansCa019.932446435920723-82035/55
Homo sapiensHYPB304107791956-205623/37
Mus musculusXP_135176380901812393-249323/37
D. melanogasterCG1716246417862262-235621/39
Neurospora crassaXP_32235532403484569-65319/37
S. pombeSPAC29B122408044703-77817/42
  • a All proteins identified contain a domain architecture similar to yeast Set2, including the AWS, SET, postSET and, in some cases, WW domains. It is notable that the putative SRI domains, as with Set2, are found in the C termini of these proteins.

  • b Identity refers to the percentage of identical amino acids present between the yeast Set2 SRI domain and the putative SRI domain of the indicated homolog, while similarity indicates amino acid replacements that exhibit similar charge or hydrophobicity.