TABLE 2.

Frequency of cell populations after 3 days of in vivo stimulation with daily injections of 0.5 mg poly(I:C)

Tissue typePhenotype% of mice with lymphocyte phenotypea
ISG15+/+ISG15−/−
ThymusCD4+ CD8+ 70.3 ± 1.572.6 ± 1.9
CD4+ CD8 18.8 ± 1.118.9 ± 1.1
CD4 CD8+ 4.3 ± 0.43.8 ± 0.5
CD4 CD8 5.8 ± 1.34.5 ± 0.6
SpleenCD3+ CD4+ 17.2 ± 1.415.6 ± 0.5
CD3+ CD8+ 8.3 ± 0.57.7 ± 0.5
B220+ IgMhigh IgDlow 50.6 ± 1.947.9 ± 1.7
B220+ IgMlow IgDhigh 1.7 ± 0.21.9 ± 0.1
Gr1high F4/80low 2.6 ± 0.12.7 ± 0.3
CD11blow F4/80low 2.6 ± 0.23.2 ± 0.5
CD11b F4/80intermediate 0.2 ± 0.00.2 ± 0.0
  • a Mean percentage ± standard error of the mean is given for groups of 5 to 12 animals analyzed in two or more independent experiments.