TABLE 2.

Comparison of biochemical parameters in Lias+/+ and Lias +/− micea

Biochemical parameterValue for mice (mean ± SEM) P valueb
Lias+/+Lias+/−
Plasma glucose (mg/dl)186 ± 9.3206 ± 17.2NS
Plasma triglyceride (mg/dl)38.1 ± 5.533.5 ± 2.3NS
Plasma cholesterol (mg/dl)56.6 ± 1.755.9 ± 2.2NS
Liver lactate (mmol/mg protein)1.16 ± 0.101.47 ± 0.130.09
Liver PDHc activity (μmol/min/mg protein)2.16 ± 0.042.04 ± 0.050.08
Plasma TBARS (nmol/ml)18.3 ± 2.120.1 ± 3.8NS
Erythrocyte GSH (mg/ml)32.3 ± 1.828.1 ± 1.70.005
  • a Data were obtained from two independent assays of nine male mice (12 to 16 weeks old) for each genotype. Data for GSH assay were acquired from 21 Lias +/+ and 19 Lias +/− mice.

  • b P value by analysis of variance. NS, not significant.

  • c PDH, pyruvate dehydrogenase.