TABLE 1.

Tumors found in wild-type and Rassf1A null micea

Type and site of tumorNo. of mice
SpontaneousIrradiated
+/+m2/m2+/+m2/m2
Lymphoma/leukemia14171820
Carcinoma
    Adenocarcinoma
        Ovary1
        Lung1241
        Gl tract1
    Squamous carcinoma of skin1
Sarcoma
    Angiosarcoma1212
    Osteogenic11
Benign
    Adenoma
        Adrenal glands1
        Lung1
        Gl tract12
    Lipoma1
    Myxoma1
    Pheochromocytoma1
    Sex cord tumor (ovary)1
  • a This table represents the different tumor types that were found; hence mice that developed multiple tumors are represented more than once. For the spontaneous cohort, 24 of the 48 Rassf1A null (m2/m2) mice died (50%) compared to 18 of the 59 wild-type mice (30%). For the irradiated cohort, 27 of the 39 Rassf1A null (m2/m2) mice died (69%) compared to 24 of the 46 wild-type mice (52%).