TABLE 2.

Functional classification of differentially expressed genes in the Pol III transcription mutants according to GOa

Biological processMutant(s)
Cellular processCell communicationResponse to extracellular stimulusResponse to extracellular starvationCellular response to nitrogen starvationtfc3
Cellular physiological processCell growth and/or maintenanceTransportHexose transporttfc3
tfc3
Physiological processMetabolismAmine metabolismAmino acid metabolismArginine biosynthesisbrf1, ΔN1, tfc3, rpc160
Arginine metabolismbrf1, ΔN1, tfc3, rpc160
Aromatic amino acid family biosynthesistfc3, rpc160
Aromatic amino acid family metabolismtfc3, rpc160
Aromatic compound biosynthesistfc3, rpc160
Aromatic compound metabolismtfc3, rpc160
Asparagine catabolismtfc3
Asparagine metabolismtfc3
Aspartate family amino acid catabolismtfc3, rpc160
Aspartate family amino acid metabolismtfc3, rpc160
Branched chain family amino acid biosynthesistfc3, rpc160
Branched chain family amino acid metabolismtfc3, rpc160
Glutamate metabolismtfc3
Glutamine family amino acid biosynthesisbrf1, ΔN1, tfc3, rpc160
Glutamine family amino acid metabolismbrf1, ΔN1, tfc3, rpc160
Lysine biosynthesisrpc160
Lysine biosynthesis, aminoadipic pathwayrpc 160
Lysine metabolismrpc 160
Nonprotein amino acid metabolismbrf1, ΔN1, tfc3, rpc160
Alcohol metabolismMonosaccharide metabolismGlycolysisrpc160
Electron transportΔ N1
Energy pathwaysEnergy derivation by oxidation of organic compoundsEnergy reserve metabolismΔ N1
Energy derivation by oxidation of organic compoundsMain pathways of carbohydrate metabolismtfc3, rpc160
Heterocycle metabolismtfc3
Macromolecule metabolismCarbohydrate metabolismΔ N1
Protein metabolismProtein foldingΔ N1
Protein metabolismPurine base metabolismtfc3
Nitrogen metabolismUrea cycle intermediate metabolismbrf1, ΔN1, tfc3, rpc160
Organic acid metabolismCarboxylic acid metabolismbrf1, ΔN1, tfc3, rpc160
Nucleobase biosynthesisPurine base biosynthesistfc3
Response to stimulusResponse to stressbrf1, ΔN1, tfc3, rpc160
  • a Only significantly enriched (P < 0.0001) GO terms (biological process) associated with at least one of the four datasets of induced genes are reported; the mutants whose modulated genes are significantly enriched in each category are reported in the last column on the right.