TABLE 3.

rad5 and rad18 mutations interact differently with other mutations affecting GCR formation

Relevant genotypeaWild typerad5Δrad18Δ
Strain numberGCR rate (CANr-5FOAr)bStrain numberGCR rate (CANr-5FOAr)bStrain numberGCR rate (CANr-5FOAr)b
Wild typeRDKY36153.5 × 10−10 (1)YKJM13852.4 × 10−8 (68)YKJM13892.3 × 10−8 (65)
mec1Δ sml1ΔRDKY37354.6 × 10−8 (131)YKJM15085.2 × 10−8 (149)YKJM15065.8 × 10−8 (166)
tel1ΔRDKY37312.0 × 10−10 (1)YKJM15141.4 × 10−9 (4)YKJM14933.0 × 10−9 (9)
est2ΔRDKY43471.2 × 10−10 (0.3)YKJM15645.9 × 10−10 (2)YKJM1562>3.4 × 10−10 (1)
pif1-m2RDKY43434.8 × 10−8 (137)YKJM13872.2 × 10−7 (629)YKJM13912.5 × 10−7 (714)
yku70ΔRDKY36391.4 × 10−9 (4)YKJM14961.2 × 10−9 (3)YKJM21375.5 × 10−9 (16)
mre11ΔRDKY36332.2 × 10−7 (629)YKJM15002.0 × 10−7 (571)YKJM14982.3 × 10−7 (657)
  • a All strains are isogenic with the wild-type strain RDKY3615 (MATa ura3-52 leu2Δ1 trp1Δ63 his3Δ200 lys2ΔBgl hom3-10 ade2Δ1 ade8 hxt13::URA3) with the exception of the indicated mutations. Parentheses indicate the rate relative to wild type.

  • b CANr-5FOAr, canavanine and 5FOA resistant.