TABLE 1.

T- and B-cell development in Sly1 d/d mutant mice a

OrganSubsetMean % positive cells ± SD Mean no. of cells/organ (106) ± SD
Wild typeSly1d/dPWild typeSly1d/dP
ThymusCD4 CD8 3.6 ± 1.46.2 ± 1.2<0.0015.1 ± 1.85.7 ± 1.80.46
CD4+ CD8+ 81.6 ± 2.879.1 ± 2.7<0.05110.5 ± 25.959.9 ± 14.5<0.001
CD4+ CD8 10.8 ± 1.49.0 ± 1.8<0.0118.7 ± 5.28.7 ± 3.9<0.001
CD8+ CD4 3.5 ± 0.94.0 ± 1.10.215.4 ± 1.83.9 ± 1.20.10
Spleen b CD4+ 61.0 ± 1.849.2 ± 3.0<0.00114.2 ± 4.47.1 ± 1.5<0.01
CD8+ 32.9 ± 1.539.7 ± 2.4<0.0016.9 ± 1.25.7 ± 1.10.11
CD25+ 2.0 ± 0.22.0 ± 0.10.861.2 ± 0.60.7 ± 0.20.20
IgMhi IgDlo 6.2 ± 2.12.7 ± 1.0<0.013.5 ± 0.91.3 ± 0.4<0.01
IgMlo IgDhi 32.3 ± 8.629.1 ± 11.80.6223.9 ± 4.115.2 ± 9.80.15
Bone marrowB220lo IgM 29.9 ± 6.025.0 ± 6.40.299.4 ± 1.410.0 ± 2.20.69
B220lo IgMlo 11.3 ± 6.013.8 ± 7.30.613.7 ± 1.76.2 ± 2.80.32
B220hi IgMhi 7.0 ± 2.54.9 ± 2.50.262.0 ± 0.71.9 ± 1.00.16
Peritoneal cavityIgMhi IgDlo 16.0 ± 2.317.2 ± 5.00.79n.d.n.d.n.d.
  • a Data are means and are derived from 6 to 12 independent mice per group.

  • b Percentages of CD4+ and CD8+ cells are relative to CD3+ cells, whereas percentages of CD25+ cells are relative to CD4 T cells.