TABLE 2.

Analysis of chromosomal abnormalities in splenocytes of Tnks2PDΔ (−/−) and Tnks2PDΔneoΔ (−/−) mice and their wild-type (+/+) littermates

GenotypeNo. of metaphases% (no./total no. of chromosomes)
Signal free endsEnd-to-end fusionsChromosome breakages
Tnks2PDΔ (+/+)1000.45 (18/3,987)0 (0/3,987)0 (0/3,987)
Tnks2PDΔ (−/−)1000.40 (16/3,992)0 (0/3,992)0 (0/3,992)
Tnks2PDΔneoΔ (+/+)1000.43 (17/3,973)0 (0/3,973)0.03 (1/3,973)
Tnks2PDΔneoΔ (−/−)1000.48 (19/3,971)0 (0/3,971)0.05 (2/3,971)