TABLE 1.

Measurement by flow-FISH of telomere length in splenocytes and thymocytes obtained from Tnks2PDΔ (−/−) and Tnks2PDΔneoΔ (−/−) mice and their wild-type (+/+) or heterozygous (+/−) littermates

Mouse typeLitterMouse no.aGenotypeTelomere lengthb
SpleenThymus
Tnks2PDΔ1M395+/+1.440.93
M396−/−1.421.04
F397+/+1.630.80
F399+/+0.671.07
F401−/−0.960.97
F402−/−1.530.59
2M443+/+0.530.98
M446−/−0.621.37
F448−/−0.961.74
F450+/+0.990.84
3F467+/+0.560.66
F468−/−0.831.04
Tnks2PDΔneoΔ1F502+/+0.770.88
F501−/−1.011.06
2F559+/+1.601.26
F560−/−1.081.05
3M628+/−0.950.87
M629−/−0.820.98
4F600+/−1.280.95
F601−/−0.920.82
F602−/−0.980.83
F604+/−0.791.15
  • a M, male; F, female.

  • b Telomere length is expressed in arbitrary fluorescent units. For Tnks2PDΔ mice, average telomere fluorescence was 0.88 (+/+) versus 1.13 (−/−) in splenocytes (P = 0.19) and 0.97 (+/+) versus 1.05 (−/−) in thymocytes (P = 0.29). For Tnks2PDΔneoΔ mice, average telomere fluorescence was 1.07 (+/+ or +/−) versus 0.94 (−/−) in splenocytes (P = 0.42) and 1.03 (+/+ or +/−) versus 0.97 (−/−) in thymocytes (P = 0.57).