TABLE 2.

Phenotypic characterization of Vp16-Meis1-induced leukemia in micea

ParameterVp16-Meis1Vp16-Meis1 + Hoxa9Control (avg)
Fresh marrowProgenitor line
No. of mice examined71154
Disease latency (days)134 ± 4974 ± 1824 ± 5NA
Organ wt (mg)
    Spleen625 ± 213723 ± 338396 ± 219106
    Lymph node58 ± 2851 ± 3915 ± 8<1
    Thymus40 ± 1851 ± 2954 ± 2729
Peripheral blood cell analysis
    WBCb (103/ml)100 ± 3658 ± 47ND3
    Granulocytes (%)74 ± 668 ± 30ND25
    Lymphocytes (%)23 ± 931 ± 27ND67
    Platelets (103/ml)370 ± 136216 ± 105ND817
    Hematocrit (%)34 ± 740 ± 10ND45
FACS analysis of marrow leukemia cells (%)
    Mac-I73 ± 1584 ± 1456 ± 33NA
    B2202 ± 10 ± 010 ± 9NA
    Thy1.22 ± 11 ± 115 ± 10NA
    Cd135 (Flt3)56 ± 3128 ± 2355 ± 33NA
Scored as AMLc465NA
Scored as MPDc350NA
  • a Values are averages ± standard derivations unless otherwise indicated. ND, not determined; NA, not applicable.

  • b WBC, white blood cells.

  • c According to the French-American-British classification, in which counts of immature myeloblasts in marrow are ≥30% for AML and ≤30% for MPD.