TABLE 1.

Echocardiographic characterization of PKD1 transgenic (PKD1-Tg) micea

CharacteristicResults by type and age (n) of mouse
Wild typePKD1-Tg
4 wk (4)6 wk (4)8 wk (3)12 wk (3)4 wk (8)6 wk (6)8 wk (6)12 wk (3)
HR707 ± 23674 ± 7694 ± 5675 ± 4639 ± 23580 ± 12598 ± 20581 ± 41
Awths (mm)1.71 ± 0.041.76 ± 0.031.81 ± 0.021.89 ± 0.041.44 ± 0.041.38 ± 0.031.19 ± 0.060.94 ± 0.04
Awthd (mm)0.93 ± 0.040.90 ± 0.010.92 ± 0.010.99 ± 0.020.79 ± 0.020.80 ± 0.020.69 ± 0.030.42 ± 0.05
PWths (mm)1.72 ± 0.051.92 ± 0.052,02 ± 0.011.99 ± 0.021.52 ± 0.021.49 ± 0.031.39 ± 0.021.37 ± 0.03
PWthd (mm)0.93 ± 0.021.03 ± 0.041.01 ± 0.031.09 ± 0.020.82 ± 0.020.85 ± 0.030.74 ± 0.060.66 ± 0.04
LVIDs (mm)0.41 ± 0.050.46 ± 0.040.43 ± 0.060.44 ± 0.011.81 ± 0.192.17 ± 0.192.62 ± 0.193.59 ± 0.44
LVIDd (mm)2.27 ± 0.082.29 ± 0.042.39 ± 0.112.38 ± 0.023.03 ± 0.243.70 ± 0.234.00 ± 0.114.76 ± 0.27
% FS81.8 ± 0.980.3 ± 0.981.1 ± 0.481.2 ± 0.444.0 ± 2.840.3 ± 2.334.4 ± 2.625.5 ± 4.0
  • a Data are expressed as means ± standard errors of the means. HR, heart rate; AWthd, anterior wall thickness in diastole; AWths, anterior wall in systole; PWthd, posterior wall thickness in diastole; PWths, posterior wall thickness in systole; LVIDd, left ventricular internal diameter in diastole; LVIDs, left ventricular internal diameter in systole; FS, left ventricular fractional shortening, calculated as (LVIDd − LVIDs)/LVIDd.