TABLE 1.

Tumorigenicity in athymic nude micea

Cell lineTumor incidenceMean tumor vol (cm3)
A549
    Parental10/101.39 ± 0.53
    shSnoN4/100.0875 ± 0.06
MDA-MB-231
    Parental10/102.00 ± 0.49
    shSnoN7/100.60 ± 0.52
  • a The indicated cells were grown as described in Materials and Methods. Five mice per cell line were injected subcutaneously in the flank bilaterally. Mice were sacrificed 60 days after injection, and tumor size was measured using hand calipers.