TABLE 2.

γ-Globin gene expression in 1.36kb γpr-βYAC transgenic micea

LineCopy no.Gene expressionb (mean ± SD) in:
Day 12 bloodDay 12 YSDay 12 FLDay 14 bloodDay 14 FLDay 16 bloodDay 16 FLAd blood
A427.3 ± 4.040.5 ± 6.218.1 ± 5.111.6 ± 0.67.3 ± 0.45.6 ± 1.24.9 ± 0.9<0.1
B226.3 ± 1.029.8 ± 7.223.4 ± 8.515.5 ± 2.06.2 ± 1.87.1 ± 0.02.7 ± 0.0<0.1
C234.6 ± 14.043.1 ± 18.17.2 ± 0.75.3 ± 0.72.6 ± 0.32.9 ± 1.12.2 ± 1.3<0.1
Avg29.4 ± 4.537.8 ± 11.516.2 ± 8.210.8 ± 5.25.4 ± 2.55.2 ± 2.13.3 ± 1.4<0.1
Αmt of γ gene expression in wt YAC29.4 ± 2.035.8 ± 10.313.2 ± 2.95.6 ± 1.32.8 ± 0.41.9 ± 0.51.2 ± 0.3<0.1
  • a YS, yolk sac; FL, fetal liver; wt, wild type; Ad, adult.

  • b Percentage of murine α-like globin genes per copy.