TABLE 1.

ε-Globin gene expression in 1.36kb γpr-βYAC transgenic micea

LineCopy no.Gene expressionb (mean ± SD) in:
Day 12 bloodDay 12 YSDay 12 FLDay 14 bloodDay 14 FL
A420.0 ± 4.623.5 ± 3.71.0 ± 0.31.6 ± 0.60.1 ± 0.0
B230.7 ± 3.331.6 ± 4.77.8 ± 0.85.7 ± 2.21.6 ± 0.6
C218.5 ± 2.518.5 ± 4.52.1 ± 0.01.7 ± 0.50.4 ± 0.0
Avg23.0 ± 6.724.5 ± 6.63.6 ± 3.63.0 ± 2.40.7 ± 0.8
Αmt of ε gene expression in wt YAC15.3 ± 1.716.5 ± 2.23.3 ± 1.42.6 ± 0.71.7 ± 0.3
  • a YS, yolk sac; FL, fetal liver; wt, wild type.

  • b Percentage of murine α-like globin genes per copy.