TABLE 4.

ε-Globin gene expressions in (1.36kb γpr-β)(ΔGγAγ) YAC transgenic micea

LineCopy no.Gene expressionb (mean ± SD) in:
Day 12 bloodDay 12 YSDay 12 FLDay 14 bloodDay 14 FL
A217.9 ± 1.719.3 ± 1.72.2 ± 0.61.1 ± 0.11.1 ± 1.0
B18.3 ± 1.19.5 ± 2.00.9 ± 0.54.1 ± 0.11.2 ± 0.3
C223.5 ± 2.623.2 ± 2.33.3 ± 0.82.8 ± 0.70.8 ± 0.1
D132.2 ± 4.634.9 ± 4.34.3 ± 0.92.8 ± 1.00.8 ± 0.8
E229.0 ± 2.837.2 ± 7.42.9 ± 0.62.8 ± 1.90.5 ± 0.3
Avg22.2 ± 9.524.8 ± 11.42.7 ± 1.32.7 ± 1.10.9 ± 0.3
Amt of ε gene expression in wt YAC15.3 ± 1.716.5 ± 2.23.3 ± 1.42.6 ± 0.71.7 ± 0.3
  • a YS, yolk sac; FL, fetal liver; wt, wild type.

  • b Percentage of α-like globin genes per copy.