TABLE 3.

Nonneoplastic pathology in Pold1+/+, Pold1+/L604G, and Pold1+/L604K micea

StrainNo. of cases (incidence [%]) of:
Chronic hepatitisCardiomyopathyHeart arteriosclerosisHeart karyomegalyGlomerulonephropathyAcidophilic macrophage pneumoniaSpleen arteriosclerosisArtery inflammationTotal nonneoplastic and neoplastic disease burden
Wild type44 (76)31 (56)31 (36)31 (65)33 (54)33 (17)36 (11)31 (9)47 (87)
+/L604G56 (77)42 (88)42 (31)42 (76)50 (62)47 (34)39 (13)42 (10)59 (88)
+/L604K54 (72)12 (83)12 (33)12 (75)34 (75)25 (36)45 (20)15 (27)64 (94)
  • a Shown are the percentages of mice with the indicated pathology, diagnosed at the end of life. These nonneoplastic lesions were the most frequently noted in the study and were graded on a 0-to-4 severity scale, where 0 is normal or no change, 1 is minimal, 2 is mild, 3 is moderate, and 4 is marked or severe. To assign a numerical representation of the amount of disease present at the end of life, we summed the neoplastic burden (Table 2) and nonneoplastic lesions determined to be contributing to morbidity or mortality (grade 3 or higher) to generate the total disease burden.