TABLE 2.

Tumor incidence and type in Pold1+/+, Pold1+/L604G, and Pold1+/L604K micea

StrainNo. (%) of:
Total miceMice with tumorsMice with no tumorsMice with malignant tumorsMice with multiple tumorsNeoplasms/mouseTumor typesEpithelial tumorsBronchiolo-alveolar tumorsHepatocellular tumorsOther tumorsMesenchymal tumorsLymphoreticular tumorsOther tumors
Wild type47 (100)29 (62)18 (38)23 (79)b9 (19)1.81020 (43)6 (13)11 (23)3 (6)17 (36)14 (30)3 (6)
L604G59 (100)46 (78)13 (22)39 (85)b15 (25)2.21133 (56)11 (19)19 (32)3 (5)31 (53)26 (44)5 (8)
L604K64 (100)45 (70)19 (30)37 (82)b6 (9)1.91323 (36)8 (13)10 (16)5 (8)28 (44)22 (34)6 (9)
  • a The number and percentage of affected mice are shown.

  • b Percentage of mice with tumors.