TABLE 1.

Role of PKCζ in Ras-induced lung gene expression

GeneExpression in lung cells with phenotypeaP valueb
WTPKCζ−/−
Vegf-A1.27 ± 0.370.32 ± 0.030.03*
Vegf-C3.91 ± 0.321.90 ± 0.340.003**
Vegf-R31.36 ± 0.380.46 ± 0.040.04*
Pecam-13.19 ± 0.411.65 ± 0.150.01*
Mip-23.07 ± 0.631.19 ± 0.120.02*
Kc1.79 ± 0.220.90 ± 0.100.02*
IL-11.66 ± 0.120.96 ± 0.200.02*
IL-43.44 ± 0.311.02 ± 0.620.008**
IL-60.44 ± 0.091.24 ± 0.180.004**
IL-12p350.27 ± 0.020.65 ± 0.120.03*
IL-12p400.91 ± 0.282.71 ± 0.480.01*
IL-23p190.31 ± 0.080.27 ± 0.480.75
IL-17F0.15 ± 0.020.17 ± 0.030.66
IL-17A0.82 ± 0.240.31 ± 0.050.08
IFNγ0.78 ± 0.281.78 ± 0.280.03*
Fhc0.67 ± 0.140.26 ± 0.020.02*
EGF2.22 ± 0.161.12 ± 0.060.03*
LIF1.80 ± 0.081.62 ± 0.090.30
Oncostatin M1.10 ± 0.101.38 ± 0.020.10
IL-113.51 ± 0.322.84 ± 0.770.20
IL6R3.21 ± 0.762.96 ± 0.250.20
gp1302.97 ± 0.353.25 ± 0.140.20
Cardiotrophin-11.19 ± 0.061.19 ± 0.010.50
  • a Values are expressed as means ± standard deviations.

  • b *, P < 0.05 versus WT value; **, P < 0.01 versus WT value.