TABLE 1.

Adenine nucleotide content and AMP/ATP and ATP/ADP ratios in EDL muscle and BAT of WT and PTP1B−/− micea

Tissue and mouse typeAdenine nucleotide content (nmol/mg protein)AMP/ATPATP/ADP
AMPADPATP
EDL muscle
    WT0.29 ± 0.033.66 ± 0.4355.61 ± 0.790.005 ± 0.00117.57 ± 2.54
    PTP1B−/−0.56 ± 0.08*3.43 ± 0.4654.71 ± 1.030.01 ± 0.001*19.16 ± 3
BAT
    WT3.08 ± 0.184.99 ± 0.358.92 ± 0.880.38 ± 0.041.91 ± 0.24
    PTP1B−/−4.57 ± 0.3*5.75 ± 0.337.66 ± 0.30.6 ± 0.03*1.37 ± 0.05
  • a Male mice on a chow diet were sacrificed in the fed state. Data are expressed as means ± SEM. n = 10 for each genotype. *, P < 0.05 compared to results for WT mice.