TABLE 2.

Metabolic characteristics of control and βTSC2−/− mice at 8 and 30 weeks of agea

Age and mouse groupBlood glucose concn (mg/dl)Plasma insulin concn (ng/ml)Concn (mg/dl) of:
FastingFedFastingFedPlasma FFAPlasma triglyceridePlasma cholesterol
8 wks
    Control56.9 ± 4.9154.0 ± 12.00.34 ± 0.080.82 ± 0.141.44 ± 0.1359.8 ± 2.771.7 ± 2.3
    βTSC2−/−41.0 ± 5.3*71.2 ± 2.9***0.84 ± 0.351.29 ± 0.291.28 ± 0.1862.5 ± 3.674.0 ± 3.0
30 wks
    Control68.4 ± 5.1126.3 ± 8.41.14 ± 0.182.39 ± 0.351.68 ± 0.0664.3 ± 3.775.6 ± 3.2
    βTSC2−/−51.4 ± 4.3*77.3 ± 5.3**2.02 ± 0.40*5.14 ± 0.74**1.42 ± 0.1963.2 ± 4.174.6 ± 3.2
  • a Data are means ± SEM (n = 10). *, P < 0.05; **, P < 0.01; ***, P < 0.001 for comparison with the corresponding value for control mice. FFA, free fatty acids.