Table 1.

Putative c-Myc target genesa

Gene productbRegulationTechniqueRelevance to c-MycReference(s)
ARF or p19UpGuessApoptosis 206
CADUpPromoterGrowth and metabolism 126
Cdc2UpGuessGrowth related 30
Cdc25AUpGuessGrowth related 64
Cyclin AUpGuessGrowth related 38, 77, 84, 91
Cyclin D1Up or downGuess/diffGrowth related 38, 139, 150
Cyclin EUpGuessGrowth related 103,137
DHFRUpPromoterGrowth and metabolism 116
ECA39UpDiffAmino acid transport 19
eIF-2αUpGuessGrowth-related metabolism 151
eIF4EUpGuessGrowth-related metabolism 92,151
ISGF3γUpGuessStress response 199
LDH-AUpDiffGrowth and metabolism 170, 180
MrDbUpBindingMetabolism 67
ODCUpDiff/guessGrowth related 18, 131, 134,136, 190, 200
PAI-1UpDiff? 141
α-ProthymosinUpDiffGrowth related 48
p53UpDiff/promoterGrowth related 148,180
RCC1UpGuessGrowth related 183
RclUpDiffGrowth related 104
TelomeraseUpGuessImmortality 193
TKUpGuessDNA metabolism 147
AlbuminDownPromoter? 106
Collagens α1(I), α2(I), α3(VI), α1(III)DownDiffAdhesion 180, 201,202
C/EBPαDownPromoterDifferentiation 106
Gadd 45DownDiffGrowth 119
Ig lambdaDownPromoter? 117
LFA-1DownGuessAdhesion 90
MHC class IDownGuessImmune surveillance 187
TdtDownPromoter? 117
ThrombospondinDownDiffMetastasis 181
  • a Note that the majority of the candidate genes have not been independently verified.

  • b Tdt, terminal deoxynucleotide transferase; Ig, immunoglobulin; diff, differential cloning; guess, candidate gene; promoter, presence of E box or Inr; MHC, major histocompatibility complex.