TABLE 2.

Analysis of gene expression in Hnf-4aloxP/loxP and Hnf-4aΔ mouse jejunums

GeneCompartmentaChange in expressionb
Transcription factors
    Hes-1C1.23c
    Math-1C1.86d
    Ngn-3V2.3e
    NeuroDV1.14c
    Sox-9C1.29c
    Hnf-4gC2.46e
    Hnf-4gV1.10c
    HNF-1aV−1.16c
    HNF-1bC1.80f
    Cdx2V−1.09c
    Klf-4V−1.35f
Enteroendocrine cell markers
    GcgV−1.56f
    GipV−1.72d
    SomatostatinV−1.72d
    SecretinV1.09c
Paneth cell markers
    MMP-7C1.13c
    Cryptdin-1C−1.33g
Goblet cell markers
    Muc2V1.97e
    Muc3V1.01c
    Tff-3V1.35g
Enterocyte cell markers
    MttpV−1.27e
    ApoBV−1.69d
    ApoA4V−1.39e
    i-FABPV−1.45d
  • a C, crypt; V, villus epithelium.

  • b Determined by quantitative real-time PCR. All values are the ratio of normalized expression levels of Hnf-4aintΔ to Hnf-4aloxP/loxP. Negative values indicate reduced gene expression in Hnf-4aintΔ compared to Hnf-4aloxP/loxP mouse intestines.

  • c No statistically significant difference.

  • d P < 0.0001.

  • e P < 0.01.

  • f P < 0.001.

  • g P < 0.05.