TABLE 1.

Characteristics of patients and tumor samples with (positive) or without (negative) overexpression of TopBP1

CharacteristicMean ± SD or n (%) for patients with TopBP1 status:P valuea
Negative (n = 33)Positive (n = 46)
Age at diagnosis (yrs; range, 28-89)52.7 ± 13.152.7 ± 12.10.989
    Race0.181
    Black6 (18.8)17 (38.6)
    White24 (75.0)24 (54.5)
    Other2 (6.3)3 (6.8)
    Unknown12
Survival0.043
    Alive29 (93.5)31 (75.6)
    Dead2 (6.5)10 (24.4)
    Unknown25
Progression0.009
    No29 (93.5)28 (68.3)
    Yes2 (6.5)13 (31.7)
    Unknown25
Tumor gradeb0.007
    01 (3.2)0
    14 (12.9)0
    215 (48.4)15 (33.3)
    311 (35.5)30 (66.7)
    Unknown21
ER status0.032
    Negative5 (17.2)17 (41.5)
    Positive24 (82.8)24 (58.5)
    Unknown45
PR status0.900
    Negative13 (44.8)19 (46.3)
    Positive16 (55.2)22 (53.7)
    Unknown45
Lymph node involvement0.369
    No13 (41.9)14 (31.8)
    Yes18 (58.1)30 (68.2)
    Unknown22
Stagec0.237
    01 (3.1)0
    14 (12.5)2 (4.4)
    215 (46.9)20 (44.4)
    311 (34.4)23 (51.1)
    41 (3.1)0
    Unknown11
Her2/Neu status0.826
    Negative21 (77.8)32 (80.0)
    Positive6 (22.2)8 (20.0)
    Unknown66
  • a P value of t test, chi-square test, or Fisher's exact test without including unknowns.

  • b Test based on the difference of tumor grades 0 to 2 versus grade 3.

  • c Test based on the difference of stages 0 to 2 versus stages 3 and 4.