TABLE 4.

Suppression of Sir3 BAH domain mutations by histone mutationsa

Sir3WT H3/H4H3 D77NH4 H75YH4 K16R
WT++++++++++++
A2V+/−+/−+
N80D+
F94L++++++++
F123P++++++++
A136T
C177R
A181V+++++++
S204P
Y207C+/−+++++++++
K209R+++++++++
Vector
  • a Different levels of silencing are indicated as +++ to − based on comparison to wild type (+++) or vector (−) phenotypes. Strains used are VSY29, VSY30, VSY31, and PYY12.