Table 2.

Interference of photoproducts with DNA replication and evidence of bypass

Cell extractFluence (J/m2)Amt of dNTP incorporated (pmol)aRF I (% of control)No. of endonuclease-sensitive sites in:
Template RF IReplicated RF I
HeLa05210000
5029551.30.5
10015302.00.9
15010204.31.4
XP variant03610000
506171.30.4
1003112.01.3
150<5
  • a dNTP, deoxynucleoside triphosphate.