TABLE 1.

Mean areas of glycolytic and oxidative fibers in the TA of control (non-CTx-treated) 3-month-old male mice with different PrPC amounts

Fiber typeMouse strainFiber area (103 μm2)a
GlycolyticWT2.53 ± 0.05 (n = 8)
KO2.56 ± 0.04 (n = 7)
Tg2.56 ± 0.06 (n = 9)
OxidativeWT1.32 ± 0.03 (n = 8)
KO1.32 ± 0.05 (n = 7)
Tg1.29 ± 0.04 (n = 9)
  • a Fibers were discriminated by a colorimetric assay that detected SDH (see Materials and Methods). As expected, glycolytic fibers had a significantly larger cross-sectional area than oxidative fibers. However, the sizes of the two populations were similarly maintained in all TAs, irrespective of the PrPC content. The data are means ± SEM.