TABLE 2.

Urine chemistrya

MeasurementMouse type
Wild typeVAMP8 null
Volume (ml)2.3 ± 0.25.4 ± 0.3
Osmolality (mOsm)2,804 ± 511,526 ± 82
Glucose (mg/dl)305 ± 57152 ± 12
Protein (mg/ml)1.27 ± 0.100.81 ± 0.06
Creatinine (mM)4.2 ± 0.41.8 ± 0.4
Chloride (mM)253 ± 11120 ± 5
Sodium (mM)215 ± 3281 ± 13
Potassium (mM)291 ± 15139 ± 9
Calcium (mM)2.3 ± 0.90.9 ± 0.3
  • a Urine was collected for 24 h from groups of six 3-month-old female mice. Data shown are means ± standard errors of the means. A total of six groups of mice of each genotype were used. P < 0.01 for all the parameters analyzed.