TABLE 2.

Comparison of organ-to-body-weight ratios for wild-type (Akt3+/+) and Akt3-deficient (Akt3−/−) miceb

OrganWeight (mg)% Body weight (relative to control)P valuea
Akt3+/+ (n = 6)Akt3−/− (n = 5)Akt3+/+ (n = 6)Akt3−/− (n = 5)
Kidney248 ± 17.7b246 ± 38.0100 ± 10.4100 ± 15.1NS
Liver1,761 ± 56.41,550 ± 169.2100 ± 7.193 ± 11.9NS
Spleen122 ± 29.1141 ± 65.4100 ± 24.4100 ± 47.8NS
Heart213 ± 45.0228 ± 22.3100 ± 23.9113 ± 17.5NS
Thymus40 ± 4.042 ± 1.1100 ± 9.5100 ± 19.2NS
Brain432 ± 23.0338 ± 20.3100 ± 9.182 ± 6.2<0.01
Body34 ± 1.9c32 ± 3.0c
  • a Comparing wild-type and Akt3−/− mice. NS, not significant (P > 0.05).

  • b Data are means ± SD.

  • c Body weights are given in grams.