Table 1.

Ets-binding sites in different genes expressed in cardiac myocytes

Source and geneaSequenceReference
r, α-MHC  +80TGTC.TTCCCT.GGAAGT.GGGGCT.CCTCCC This study
r, α-MHC −109CAGA.CAGGAG.GGATGG.GAGGGA.GGGTCC 30
m, α-MHC  +86TGCC.TTTCCT.GGAAGT.GGGGTT.CAGGCC.GGTC 13
m, α-MHC −102AGGA.CAGGAG.GGAAGT.GGGAGG.GAGGGT.CC 13
rb, α-MHC (AS)  +57TCCC.TGGGAC.GGAAGG.ACCCTC.ACTCGT.CGT 9a
rb, α-MHC +106GGGT.TCTGCT.GGAAGC.GCCCTT.CTCCAG.CC 9a
rb, α-MHC  −88GGGT.CCCTCC.GGAAGG.GCTCCA.AATTTA.GG 9a
h, α-MHC +149CCAG.GCCCAG.GGAAG T.TCCCCC.TGACAC.AGGA 62
h, α-MHC  −95AGGG.TCCTCC.GGAAGG.ACTCCA.AATTTA.GA 62
sh, α-MHC  +86TGCC.TTCCCT.GGAAGT.GGGGCT.TAGGGC.CGTC 69
sh, α-MHC −311GGCC.ATGTGG.GGAAGG.GAGGTG.GCGTGC.TATG 69
r, β-MHC −147TTCG.GACAAG.GGAAGG.GGGGGA.GAGTT 65
r, β-MHC (AS) −174GGAA.ACAATT.GGAAGT.GGGCGT.CATTGT.TA 65
m, β-MHC  +81TCCA.GGTTCA.GGAAGT.AATTCC.TCTAGA.ACA 48
m, β-MHC (AS) −175GGAA.ACAATT.GGAAGT.GGTCGT.CATTGT.TGT 48
h, β-MHC −147GCAC.TGTTTG.GGAAGG.GGGGGA.GCCTCG 26
h, β-MHC (AS) −177GGAA.ACAATT.GGAAGT.GGTCGT.CATTGT.TA 26
rb, β-MHC (AS) −162GGAA.ACAATT.GGAAGT.GGTCGT.CATTGT.TA 58
rb, β-MHC  +63TCCC.AGGTTA.GGAAGG.GGCTCC.CCCAGG.AACA 9a
r, MLC-2  −47TTAA.CCCCAG.GGAAGA.GGTATT.TATTGT.TCCAA 18
r, MLC-2 (AS) −272AAGT.AACCCA.GGAAGG.GGAGGG.GGGAGG.AAGA 18
c, MLC-2 −257CCAG.CAGAGG.GGAAGA.GCACAG.CCTCTG.CCCAC 57
c, C-TnT −167CTCC.TGTGGG.GGAAGG.GGGAGC.ACGGAG.GGGG 22
m, C-Tnc +142GGTA.CACTAG.GGAAGT.GATGGG.GGACTC.AAAA 44
m, C-Tnc −645ACCT.TGCATA.GGAAGT.GTTTCT.TGGCAG.GACTT 44
m, C-TnI −833TTCC.TTTCCT.GGAACT.CTCGGT.TGTACT.ATTTT 1
m, C-TnI −250TATG.AACATG.GGAAGC.TGAAGT.CTAGAC.T 1
r, ANF −289CGAG.CGCCCA.GGAAGA.TAACCA.AGGACT.CTTTT 55
r, ANF−1139ATGT.GGGTAT.GGAAGT.CTTCCA.ATAGCC.CATA 55
m, MCK (AS) −251CCCT.TCGCCG.GGAACA.TGGAAC.AGTAAT.AC 59
m, MCK −221ACTT.AGTTTA.GGAACC.AGTGAG.CAAGTC.AG 59
sh, MHC −128AAAA.ATACGT.GGAAGG.GGCCAG.TTCTCA.GCTT 33
sh, MHC −317CAGG.GTGGGA.GGAACT.GCAGGA.GTCAAG.GCAG 33
q, slow MHC-3 −395GCAC.AGTGTG.GGAACT.ATGGGG.CAGAGG.CTT 41
q, slow MHC-3 −324GGGC.ACAACG.GGAACT.GGGGGG.CAGAGG.G 41
m, C-α-actin (AS) −386GTCA.CATGGC.GGAAGA.CTTGGC.GCCCTG.CCCT 34
h, C-α-actin (AS) −266AGGG.GGCAGG.GGAAGA.CTAAGT.GACGCC.AGC 34
c, C-α-actin (AS) −258GGTC.CCTCGA.GGAAGT.GTAAGC.CAGG 11
m, Sk-α-actin −339GTAA.ATCTTG.GGAAGT.ACAGAC.CAGCGG.TCA 21
m, Sk-α-actin  −92ATAT.GGCTTG.GGAAGG.GCAGCA.ACATTC.TTC 21
r, Sk-α-actin  −90ATAT.GGCTTG.GGAAGG.GCAACA.ACATTC.CT 21
c, Sk-α-actin (AS)  −46GCCC.GCGACA.GGAATG.CGACCC.CGG 21
Ets-binding core sequence GGA (A/T)
  • a Sources: r, rat; m, mouse; h, human; sh, Syrian hamster; rb, rabbit; q, quail; c, chicken. AS, antisense DNA. Sequences similar to the rat α-MHC gene Ets-binding site are shown boldface and other, adjacent sites are underlined.