Table 1.

Mechanisms of transcriptional regulation by CHOP after ER stress

MechanismElementTarget gene(s)Effect
Dominant inhibitionCCAATC/EBPα (?), angiotensinogenInhibition of adipocyte differentiation; acute-phase response
DNA binding and transactivationTGCAATCarbonic anhydrase VIIntracellular pH control(?), apoptosis(?)
Tethering to AP-1 and CRE control elementsTGACTCA, TGACGTCAJunD(?), somatostatin(?), collagenase(?), others(?)Apoptosis(?), defense responses to stress(?), cell cycle control(?)