Table 2.

Functions of proteins listed in Table 1

NameaYPD title linesb
Adh1Alcohol dehydrogenase I; cytoplasmic isozyme reducing acetaldehyde to ethanol, regenerating NAD+
Adh2Alcohol dehydrogenase II; oxidizes ethanol to acetaldehyde, glucose repressed
Cit2Citrate synthase, peroxisomal (nonmitochondrial); converts acetyl-CoA and oxaloacetate to citrate plus CoA
Eno1Enolase 1 (2-phosphoglycerate dehydratase); converts 2-phospho-d-glycerate to phosphoenolpyruvate in glycolysis
Eno2Enolase 2 (2-phosphoglycerate dehydratase); converts 2-phospho-d-glycerate to phosphoenolpyruvate in glycolysis
Fba1Fructose bisphosphate aldolase II; sixth step in glycolysis
Hxk1Hexokinase I; converts hexoses to hexose phosphates in glycolysis; repressed by glucose
Hxk2Hexokinase II; converts hexoses to hexose phosphates in glycolysis and plays a regulatory role in glucose repression
Icl1Isocitrate lyase, peroxisomal; carries out part of the glyoxylate cycle; required for gluconeogenesis
Pdb1Pyruvate dehydrogenase complex, E1 beta subunit
Pdc1Pyruvate decarboxylase isozyme 1
Pfk1Phosphofructokinase alpha subunit, part of a complex with Pfk2p which carries out a key regulatory step in glycolysis
Pgi1Glucose-6-phosphate isomerase, converts glucose-6-phosphate to fructose-6-phosphate
Pyc1Pyruvate carboxylase 1; converts pyruvate to oxaloacetate for gluconeogenesis
Tal1Transaldolase; component of nonoxidative part of pentose phosphate pathway
Tdh2Glyceraldehyde-3-phosphate dehydrogenase 2; convertsd-glyceraldehyde 3-phosphate to 1,3-dephosphoglycerate
Tdh3Glyceraldehyde-3-phosphate dehydrogenase 3; convertsd-glyceraldehyde 3-phosphate to 1,3-dephosphoglycerate
Tpi1Triosephosphate isomerase; interconverts glyceraldehyde-3-phosphate and dihydroxyacetone phosphate
Efb1Translation elongation factor EF-1β; GDP/GTP exchange factor for Tef1p/Tef2p
Eft1Translation elongation factor EF-2; contains diphthamide which is not essential for activity; identical to Eft2p
Eft2Translation elongation factor EF-2; contains diphthamide which is not essential for activity; identical to Eft1p
Prt1Translation initiation factor eIF3 beta subunit (p90); has an RNA recognition domain
Rpa0 (RPPO)Acidic ribosomal protein A0
Tif1Translation initiation factor 4A (eIF4A) of the DEAD box family
Tif2Translation initiation factor 4A (eIF4A) of the DEAD box family
Yef3Translation elongation factor EF-3A; member of ATP-binding cassette superfamily
Hsc82Chaperonin homologous to E. coli HtpG and mammalian HSP90
Hsp60Mitochondrial chaperonin that cooperates with Hsp10p; homolog of E. coli GroEL
Hsp82Heat-inducible chaperonin homologous to E. coliHtpG and mammalian HSP90
Hsp104Heat shock protein required for induced thermotolerance and for resolubilizing aggregates of denatured proteins; important for [psi]-to-[PSI+] prion conversion
Kar2Heat shock protein of the endoplasmic reticulum lumen required for protein translocation across the endoplasmic reticulum membrane and for nuclear fusion; member of the HSP70 family
Ssa1Cytoplasmic chaperone; heat shock protein of the HSP70 family
Ssa2Cytoplasmic chaperone; member of the HSP70 family
Ssb1Heat shock protein of HSP70 family involved in the translational apparatus
Ssb2Heat shock protein of HSP70 family, cytoplasmic
Ssc1Mitochondrial protein that acts as an import motor with Tim44p and plays a chaperonin role in receiving and folding of protein chains during import; heat shock protein of HSP70 family
Sse1Heat shock protein of the HSP70 family; multicopy suppressor of mutants with hyperactivated Ras/cyclic AMP pathway
Sti1Stress-induced protein required for optimal growth at high and low temperature; has tetratricopeptide repeats
Ade1Phosphoribosylamidoimidazole-succinocarboxamide synthase: catalyzes the seventh step in de novo purine biosynthesis pathway
Ade3C1 tetrahydrofolate synthase (trifunctional enzyme), cytoplasmic
Ade5,7Phosphoribosylamine-glycine ligase plus phosphoribosylformylglycinamidine cyclo-ligase; bifunctional protein
Arg4Argininosuccinate lyase; catalyzes the final step in arginine biosynthesis
Gdh1Glutamate dehydrogenase (NADP+); combines ammonia and α-ketoglutarate to form glutamate
Gln1Glutamine synthetase; combines ammonia to glutamate in ATP-driven reaction
His4Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase/histidinol dehydrogenase; 2nd, 3rd, and 10th steps of his biosynthesis pathway
Ilv5Ketol-acid reductoisomerase (acetohydroxy, acid reductoisomerase) (alpha-keto-β-hydroxylacyl) reductoisomerase); second step in Val and Ilv biosynthesis pathway
Lys9Saccharopine dehydrogenase (NADP+,l-glutamate forming) (saccharopine reductase), seventh step in lysine biosynthesis pathway
Met6Homocysteine methyltransferase; (5-methyltetrahydropteroyl triglutamate-homocysteine methyltransferase), methionine synthase, cobalamin independent
Pro2γ-Glutamyl phosphate reductase (phosphoglutamate dehydrogenase), proline biosynthetic enzyme
Ser1Phosphoserine transaminase; involved in synthesis of serine from 3-phosphoglycerate
Trp5Tryptophan synthase, last (5th) step in tryptophan biosynthesis pathway
Act1Actin; involved in cell polarization, endocytosis, and other cytoskeletal functions
Adk1Adenylate kinase (GTP:AMP phosphotransferase), cytoplasmic
Ald6Cytosolic acetaldehyde dehydrogenase
Atp2Beta subunit of F1-ATP synthase; 3 copies are found in each F1 oligomer
Bmh1Homolog of mammalian 14-3-3 protein; has strong similarity to Bmh2p
Bmh2Homolog of mammalian 14-3-3 protein; has strong similarity to Bmh1p
Cdc48Protein of the AAA family of ATPases; required for cell division and homotypic membrane fusion
Cdc60Leucyl-tRNA synthetase, cytoplasmic
Erg20Farnesyl pyrophosphate synthetase; may be rate-limiting step in sterol biosynthesis pathway
Gpp1 (Rhr2) dl-Glycerol phosphate phosphatase
Gsp1Ran, a GTP-binding protein of the Ras superfamily involved in trafficking through nuclear pores
Ipp1Inorganic pyrophosphatase, cytoplasmic
Lcb1Component of serine C-palmitoyltransferase; first step in biosynthesis of long-chain base component of sphingolipids
Mol1 (Thi4)Thiamine-repressed protein essential for growth in the absence of thiamine
Pab1Poly(A)-binding protein of cytoplasm and nucleus; part of the 3′-end RNA-processing complex (cleavage factor I); has 4 RNA recognition domains
Psa1Mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase
Rnr4Ribonucleotide reductase small subunit
Sam1 S-Adenosylmethionine synthetase 1
Sam2 S-Adenosylmethionine synthetase 2
Sod1Copper-zinc superoxide dismutase
Uba1Ubiquitin-activating (E1) enzyme
YKL056Resembles translationally controlled tumor protein of animal cells and higher plants
YLR109 (Ahp1)Alkyl hydroperoxide reductase
YMR116 (Asc1)Abundant protein with effects on translational efficiency and cell size, has two WD (WD-40) repeats
  • a Accepted name from theSaccharomyces genome database and YPD. Names in parentheses represent recent changes.

  • b Courtesy of Proteome, Inc., reprinted with permission.