Table 1.

Each of the three classes of ER-interacting LXXLL motifs is found within known coactivators

ClassCoactivatorSequencea
Class ISRLXXLL
GRIP1TKLLQLL
SRC-1HKLVKLL
AIB-1KKLLQLL
Class II LXXLL
TRAP220 PILTSLL
PMLMNLL
RIP140 PILYYML
Class III (S/T)ΦLXXLL
RIP140 TYLEGLL
TLLASLL
SLLLHLL
TLLQLLL
TVLQLLL
PGC-1 SLLKKLL
DAX-1 SILYNLL
SILYSML
SILYSLL
SHP TILYALL
SILKKIL
  • a X, any amino acid; Φ, hydrophobic amino acid. Conserved amino acids in each class are in boldface type.