Table 3.

Hemopoietic parameters of wild-type and Cbl−/− mice

ParameterValue (± SD) for genotype:P value
+/+−/−
Blood
 Leukocytes (106/ml)8.5 ± 1.210.9 ± 1.3NSb
 Erythrocytes (109/ml)9.3 ± 0.59.3 ± 0.6NS
 Platelets (109/ml)1,091 ± 391,755 ± 87<0.001
 Reticulocytes (109/ml)0.39 ± 0.030.40 ± 0.06NS
 Packed cell vol (%)46.9 ± 1.246.3 ± 0.9NS
Spleen
 Wt (mg)79.6 ± 5.8136.6 ± 9.7<0.001
 CFC/104cells30.5 ± 8.665.8 ± 17.8NSc
Bone marrow
 Cells/femur (107)2.3 ± 0.32.0 ± 0.2NS
 CFC/femur (106)a 5.55 ± 1.546.02 ± 1.38NS
Thymus cellularity (107)
 5–5.5 wk old16.3 ± 2.024.8 ± 1.3<0.005
 7–9 wk old16.1 ± 1.614.9 ± 1.5NS
Lymph node cellularity (106)16.3 ± 2.231.7 ± 3.7 0.004
  • a CFC responsive to CSF-1 alone were assayed as an index of the committed progenitor cell compartment (5).

  • b NS, not significant.

  • c The incidence of spleen CFC appeared elevated in Cbl−/− mice but did not reach statistical significance (P = 0.1).