Table 1.

Specificity of HDV editing in transfected Huh-7 cells

RNA (no. of clones analyzed)No. (%) with:A→G changes at amber/W as % of all A→G changesaNon-amber/W A→G changes/RNA
Modifications at amber/WNon-amber/W A→G changesNon-A→G changes
Replicating (84)24 (29)3 (0.05b)9 (0.03)c 890.16
Nonreplicating (97)35 (36)7 (0.09)1 (.003)830.32
  • a (No. of clones edited at the amber/W site)/(total no. of A→G changes)] × 100.

  • b % = [(no. of changes)/(no. of adenosines × no. of clones)] × 100.

  • c For replicating RNA, includes four U→C changes.