Table 1.

Tumorigenicity of NIH 3T3 cells expressing PKR variants

CloneNo. of tumorsaLatency (days)
pcDNA3 (vector)0>21b
Wild-type PKR0>21c
K296R47–14
Δ647–10
T451A410–11
T446A,T451A412–14
S242A,T255A,T258A412–14
  • a Four animals were used for each clone.

  • b A tumor appeared in 1 mouse after 96 days.

  • c Tumors appeared in 3 mice at 59 to 80 days.