Table 3.

Stimulation of translocations by DNA-damaging agents inRAD9 + andrad9::URA3 diploids

AgentStimulation in RAD9+ (YB110a)Stimulation inrad9(YB134a)Ratioc
Concn or doseSurvival (%)His+/107CFUbConcn or doseSurvival (%)His+/107 CFU
MMS0.1%9459 ± 130.1%81246 ± 214.2
10.5 mM10.5 mM
UV150 J/m2 9498 ± 12150 J/m2 68733 ± 1837.5
120 J/m2 9752 ± 12120 J/m2 67563 ± 9811
60 J/m2 9838 ± 1060 J/m2 89296 ± 577.8
γ rays23.4 Kilorads76314 ± 4423.4 Kilorads21984 ± 2123.1
15.6 Kilorads79192 ± 615.6 Kilorads381,056 ± 1975.5
7.8 Kilorads9485 ± 57.8 Kilorads76587 ± 1216.9
3.9 Kilorads10031 ± 53.9 Kilorads95212 ± 456.8
X rays2.2 Kilorads889 ± 42.2 Kilorads77137 ± 3715
880 Rads864 ± 4880 Rads8943 ± 3111
  • a For complete genotypes, see Table 1.

  • b (His+ frequency with agent − His+ spontaneous frequency) × 107;n = 3.

  • c (His+/107 CFU forrad9)/(His+/107 CFU forRAD9+ ). Spontaneous frequency of YB110 = (6.2 ± 3.2) × 10−8 (n = 33); spontaneous frequency of YB134 = (6.9 ± 2.1) × 10−7 (n = 33).