Table 3.

Levels of serum growth factors in HNF-1α knockout micea

Age (wk) and typeGH (ng/ml) in miceIGF-I (ng/ml) in miceInsulin (ng/ml)
MaleFemaleMaleFemale
5
 +/+2.1 ± 0.51.7 ± 1.3426 ± 29430 ± 56ND
 +/−4.1 ± 3.53.0 ± 1.9423 ± 50495 ± 250.53 ± 0.05
 −/−91.5 ± 13.0118.0 ± 28.0147 ± 47115 ± 230.29 ± 0.06 (P < 0.01)
12
 +/+6.1 ± 2.84.5 ± 2.1248 ± 35434 ± 52ND
 +/−7.5 ± 4.12.8 ± 0.4236 ± 42317 ± 430.54 ± 0.16
 −/−25.4 ± 9.331.8 ± 14.7129 ± 8103 ± 30.34 ± 0.13 (P < 0.10)
  • a Serum was collected from groups of mice of either genotype at two different ages and subjected to analysis for levels of GH, IGF-I, and insulin. Values presented are the means ± standard errors for at least three serum samples. Pvalues indicate significance for knockout mice with respect to control mice at the same age. ND, not determined.