Table 2.

Urine chemistry of 6-week-old HNF-1α knockout micea

ComponentLevel in Hnf-1α mice
+/−−/−b
Glucose (mg/dl)17 ± 25,600 ± 2,510 (330)
ALP (U/liter)44 ± 2029 ± 6 (0.7)
GGT (U/liter)40 ± 1111 ± 3 (0.3)
Creatinine (mg/dl)16 ± 18 ± 1 (0.5)
Protein (mg/dl)167 ± 17209 ± 42 (1.3)
Sodium (meq/liter)55 ± 1249 ± 6 (0.9)
Potassium (meq/liter)78 ± 352 ± 9 (0.7)
Phosphorus (mg/dl)133 ± 880 ± 2 (0.6)
  • a Urine was collected from groups of mice of either genotype and subjected to analysis for levels of glucose, alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT), creatinine, protein sodium, potassium, and phosphorus. Values presented are the means ± standard errors for three serum samples.

  • b Values in parentheses are the fold increase or decrease for knockout versus control mice.