Table 1.

Summary of biological characteristics of the wild-type and mutant STAT5As

ProteinTP and DNA bindingaTranscriptional activationbNuclear localizationcFId
STAT5A (wild type)
STAT5A1++
STAT5A6+
STAT5A1*6+++++
  • a Tyrosine phosphorylation (TP) and DNA binding in the absence of IL-3 stimulation were assessed by Western blotting and EMSA, respectively.

  • b Transcriptional activation in the absence of stimulation was assessed by the luciferase assay.

  • c Nuclear localization in NIH 3T3 cells.

  • d Induction of FI proliferation.