Table 3.

Proportion of IR-A mRNA and total IR content in normal and cancer specimens from human breast, lung, and colon

Tissue (no. of specimens)Proportion (%) of IR-AaP valueIR content (ng/0.1 μg of protein)
RangeMedian
Breast cancer (n = 12)40–80733.2 ± 1.8
Normal breast (n = 12)30–50430.0050.5 ± 0.3
Lung cancer (n = 6)30–60531.1 ± 0.3
Normal lung (n = 6)30–55390.0650.5 ± 0.1
Colon cancer (n = 10)65–80681.8 ± 0.5
Normal colon (n = 10)30–65350.011.3 ± 0.4
  • a As determined by RT-PCR.

  • b Wilcoxon signed-rank test.