Table 1.

Activation of B element activity by PDX1

PDX1Activitya of the B element in transfected:
HeLa cells266-6 cells
BB-P2b
Absent0.120.0420
Presentc 120.02180
Fold increase1000.59
  • a Amount of expression (nanograms of hGH) of the B-element-driven hGH reporter gene (5B.EIp.hGH).

  • b This B-element mutant has two base pair changes in the PBX binding motif that abolish PBX binding (Fig. 8).

  • c Cotransfection with the PDX1 expression plasmid. Transfections without the PDX1 expression plasmid contained an equal amount of the pBKCMV expression vector without insert.