Table 1.

Functional analysis of FANCA mutant proteins

ProteinFA-A cell complementationFANCC bindingNuclear localizationFANCG binding
Wild-type FANCA++++
FANCA-ΔNLS
SV40T-FANCA+
FANCA-NLS-mut2
FANCA-ΔXho+
FANCA(H1110P)+
FANCA(R1117G)+