TABLE 1

Downregulated miRNAs (<0.5-fold change) in skeletal muscles of a dbTg1 mouse (n = 1) compared with those in a WT mouse (n = 1)

miRNAbFold changeTissue distributionTarget(s) in skeletal muscleaReference(s)
mmu-miR-29c*0.21UnclearUnclear
mmu-miR-1930.28Brown adipose tissueCdon, Igfbp558
mmu-miR-193b0.37
mmu-miR-3780.32MuscleMyoR, IGF1R47, 59
mmu-miR-29c0.32UbiquitousYY160, 61
mmu-miR-31070.32UnclearUnclear
mmu-miR-1850.33UnclearUnclear
mmu-miR-3650.33Brown adipose tissueUnclear58
mmu-miR-1360.40UnclearUnclear
mmu-miR-30a*0.42UnclearUnclear
mmu-miR-133a*0.42UnclearUnclear
mmu-miR-133a0.43MuscleSRF, nPTB, UCP246, 62, 63
mmu-miR-133b0.47
mmu-miR-196a0.44UnclearUnclear
mmu-miR-30a0.44UbiquitousSnai16466
mmu-miR-30c0.45
mmu-miR-345-5p0.45UnclearUnclear
mmu-miR-30e*0.46UnclearUnclear
mmu-miR-151-5p0.47UnclearPLM67
mmu-miR-101b0.48UnclearUnclear
mmu-miR-378*0.48UnclearUnclear
mmu-miR-10.49MuscleHDAC4, Cx43, Pax7, c-Met, G6PD46, 52, 6870
mmu-miR-3610.49UnclearUnclear
  • a IGF1R, insulin-like growth factor 1 receptor; SRF, serum response factor; HDAC4, histone deacetylase 4; G6PD, glucose-6-phosphate dehydrogenase.

  • b Asterisks indicate the antisense form of miRNA.