TABLE 1

Gene ontology analysis of biological processes enriched in genes exhibiting decreased and increased expression levels with ERH knockdown in comparison to nontargeting siRNA controls

Biological processNo. of genesP valueq value
Decreased expression
    Cell cycle process1255.41 × 10−437.26 × 10−39
    Chromosome organization491.49 × 10−232.22 × 10−20
    Cell division497.09 × 10−199.53 × 10−16
    Chromatin assembly or disassembly242.27 × 10−161.79 × 10−13
    DNA metabolic process671.07 × 10−157.55 × 10−13
    Chromatin organization622.68 × 10−151.71 × 10−12
    Microtubule-based process505.58 × 10−153.4 × 10−12
    Nuclear division388.89 × 10−144.42 × 10−11
    Chromosome segregation224.87 × 10−142.51 × 10−11
    Protein complex assembly749.44 × 10−144.53 × 10−11
    Spindle organization204.52 × 10−131.9 × 10−10
    Organelle fission381.46 × 10−125.92 × 10−10
    Macromolecular complex assembly782.07 × 10−116.19 × 10−9
    Cell cycle checkpoint236.25 × 10−101.38 × 10−7
    Sister chromatid segregation101.09 × 10−92.28 × 10−7
    DNA conformation change182.08 × 10−94.17 × 10−7
    Regulation of organelle organization671.14 × 10−81.94 × 10−6
    DNA repair363.34 × 10−85.34 × 10−6
    DNA replication167.7 × 10−56.08 × 10−3
Increased expression
    Regulation of intracellular signal transduction871.3 × 10−91.75 × 10−5
    Regulation of cell death884.18 × 10−87.02 × 10−5
    Regulation of cell proliferation864.44 × 10−85.97 × 10−5
    Positive regulation of signaling831.73 × 10−71.66 × 10−4
    Extracellular matrix organization332.53 × 10−72.12 × 10−4
    Cell adhesion643.63 × 10−72.21 × 10−4
    Cell motility543.76 × 10−72.1 × 10−4
    Positive regulation of cell communication824.47 × 10−72.22 × 10−4
    Regulation of hydrolase activity702.59 × 10−69.4 × 10−4
    Regulation of protein metabolic process1153.35 × 10−61.07 × 10−3
    Glycosaminoglycan biosynthetic process149.11 × 10−62.45 × 10−3
    Aminoglycan biosynthetic process141.02 × 10−52.69 × 10−3
    Positive regulation of response to stimulus921.35 × 10−53.12 × 10−3
    Regulation of proteolysis457.08 × 10−59.41 × 10−3
    Epithelium development208.99 × 10−51.14 × 10−2
    Tissue development391.07 × 10−41.28 × 10−2
    Regulation of cellular component movement401.24 × 10−41.43 × 10−2
    Chemotaxis207.57 × 10−45.01 × 10−2