TABLE 2

Gene ontology analysis of biological processes enriched in genes exhibiting defective mRNA splicing in ERH-deficient cells in comparison to nontargeting controls

Biological processNo. of genesP valueq value
Nucleosome assembly205.4 × 10−96.57 × 10−5
Protein heterotetramerization102.4 × 10−81.46 × 10−4
Protein-DNA complex assembly212.96 × 10−81.2 × 10−4
Nucleosome organization216.05 × 10−81.84 × 10−4
Chromatin silencing at ribosomal DNA101.16 × 10−72.82 × 10−4
DNA replication-dependent nucleosome organization91.31 × 10−72.65 × 10−4
DNA replication-dependent nucleosome assembly91.31 × 10−72.27 × 10−4
DNA methylation121.02 × 10−61.24 × 10−3
DNA alkylation121.02 × 10−61.13 × 10−3
Chromatin silencing101.87 × 10−51.75 × 10−2
DNA modification134.6 × 10−53.73 × 10−2
Methylation271.38 × 10−49.29 × 10−2
Chromatin assembly or disassembly122.29 × 10−41.46 × 10−1
Gene silencing122.62 × 10−41.59 × 10−1
Protein heterooligomerization122.99 × 10−41.65 × 10−1
Negative regulation of hematopoietic progenitor cell differentiation53.13 × 10−41.66 × 10−1
Regulation of response to external stimulus404.29 × 10−42.17 × 10−1
Reciprocal meiotic recombination66.42 × 10−43 × 10−1
Reciprocal DNA recombination66.42 × 10−42.89 × 10−1
Regulation of megakaryocyte differentiation59.36 × 10−44.06 × 10−1