TABLE 1

Mutation analysis of nonselected TSCE5 and BLM-TSCE5 mutants after I-SceI expression

Mutation typeNo. (%) of mutantsa
TSCE5 cells (480 clones)BLM-TSCE5 cells (480 clones)
Small deletion (<60 bp)8 (53)18 (49)
Medium-sized deletion (60 bp–1 kb)3 (20)3 (8.1)
Large deletion (>1 kb)06 (16)
Insertion (1 bp)02 (5.4)
Rearrangement4 (27)5 (14)
Recombination02 (5.4)
Translocation01 (2.7)
Total15 (3.1)37 (7.7)
  • a Except for the last row. The data in the last row are numbers (%) among all clones.